|
KMID : 1149220120200010041
|
|
Korean Journal of Oriental Medical Prescription
2012 Volume.20 No. 1 p.41 ~ p.49
|
|
|
Anti-inflammatory effects of HC001 on atopic dermatitis-like skin lesions in mice
|
|
Choi You-Youn
Kim Mi-Hye
Kum Chang-Jun
Choi Young-Jin
Hwang Man-Ki
Sohn Young-Joo
Jung Hyuk-Sang
Yang Woong-Mo
|
|
|
Abstract
|
|
|
Objectives: The purpose of this study is to examine the effects of external application of HC001 on atopic dermatitis. HC001, newly composed herbal medicine combinations contains 9 medicinal herbs which are known to have anti-inflammatory and anti-allergic effects. We investigated the anti-inflammatory effects of HC001 on atopic dermatitis-like skin lesions in mice.
Methods: Seven-week-old BALB/c mice were sensitized with DNCB to develop atopic dermatitis. Animals were divide into three group: Normal, DNCB (Negative control group), HC001 (Experimental group, treated with DNCB and HC001). Skin sections were stained with H&E to measure the thicknesses of the epidermis and dermis, respectively. The expression of NF- ĸβ protein was measured by western blotting analysis in skin lesion.
Results: Topical HC001 treatment significantly restored the skin thickening and hyperplasia of the epidermis and dermis compared with DNCB-sensitized group in histopathological analyse. In addition, HC001 inhibited the expression of NF-ĸβ protein increased in DNCB-induced atopic dermatitis-like skin lesions in mice.
Conclusions: These results suggest that HC001 may be useful as an external application agent for atopic dermatitis based on reductions of various inflammatory responses.
|
|
|
KEYWORD
|
|
|
Atopic dermatitis, Anti-inflammation, HC001, NF- ĸβ
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|